N-acetylcysteine, ascorbic acid, and methylene blue for the treatment of aluminium phosphide poisoning: Still beneficial?

Fatal aluminium phosphide poisoning

Aluminium phosphide (AlP) is a cheap solid fumigant and a highly toxic pesticide which is commonly used for grain preservation. AlP has currently aroused interest with a rising number of cases in the past four decades due to increased use for agricultural and non-agricultural purposes. Its easy availability in the markets has increased also its misuse for committing suicide. Phosphine inhibits ...

Successful Treatment of Aluminium Phosphide Poisoning: A Case Report

Aluminium phosphide (AlP) is used to kill rodents in grain storage. It produces phosphine gas which is toxic for mitochondria. The exact mechanism of action is unclear, but phosphine is thought to produce toxicity by blocking cytochrome-c oxidase, which inhibits oxidative phosphorylation and result in cell death. This poisoning has a high mortality, and survival is unlikely if more than 1.5 g i...

Aluminium phosphide poisoning.

We describe a lethal poisoning in a healthy woman caused by deliberate ingestion of aluminium phosphide (AlP), a pesticide used to kill rodents and insects. Toxicity of AlP and review of cases reported to the National Poisons Information Service (London) 1997-2003 are discussed.

Aluminium Phosphide Poisoning

Need for antidote for aluminium phosphide poisoning.

Human toxicity of aluminium phosphide occurs due to the toxic effects of phosphine which is liberated in stomach on ingestion (1). The effect is worse in the presence of hydrochloric acid in the stomach. It is widely absorbed from gastrointestinal tract and has cytotoxic action as it inhibits mitochondrial respiration. It affects almost all systems i.e. gastrointestinal, cardiovascular, respira...